Autophagy and the immune function in aging
نویسندگان
چکیده
منابع مشابه
Autophagy in aging and disease.
Autophagy is a catabolic degradation system used to destroy and recycle the unnecessary or damaged components of a cell. Autophagy is present at a basal level in all mammals and is regulated by some conditions, such as oxidative stress, starvation or hypoxia. In aged tissues, increased but also decreased expression of autophagy-specific proteins, Beclin 1, LC3, Atg5 and Atg7 has been reported. ...
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Sabrina Schroeder 1,# , Andreas Zimmermann 1,# , Didac Carmona-Gutierrez 1 , Tobias Eisenberg 1 , Christoph Ruckenstuhl 1 , Aleksandra Andryushkova 1 , Tobias Pendl 1 , Alexandra Harger 1,2 and Frank Madeo 1, * 1 Institute of Molecular Biosciences, University of Graz, Humboldtstrasse 50, 8010 Graz, Austria. 2 Division of Endocrinology and Metabolism, Dept. of Internal Medicine, Medical Universi...
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The aging population is increasing in developed countries. Because the incidence of cardiac disease increases dramatically with age, it is important to understand the molecular mechanisms through which the heart becomes either more or less susceptible to stress. Cardiac aging is characterized by the presence of hypertrophy, fibrosis, and accumulation of misfolded proteins and dysfunctional mito...
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A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related manifestations. In this work we review the molecular defects responsible for the malfunctioning of two forms of autophagy, macroautophagy and chaperone-mediated ...
متن کاملAutophagy and Aging
Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of cal...
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ژورنال
عنوان ژورنال: Current Opinion in Immunology
سال: 2014
ISSN: 0952-7915
DOI: 10.1016/j.coi.2014.05.006